Summary: The long-term use of proton pump inhibitors (PPIs), a class of drugs commonly used to treat acid reflux, is linked to a more than doubling in the risk of developing stomach cancer, finds research summarized in ScienceDaily, October 2017.
The authors noted, “the longer PPIs were used, the greater was the risk of developing stomach cancer, rising to 5-fold after more than a year, to more than 6-fold after two or more years, and to more than 8-fold after three or more years.”
“Long-term use of drugs to curb acid reflux linked to doubling in stomach cancer risk: Risk rose in tandem with dose and duration of proton pump inhibitor (PPI) treatment.”
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Ka Shing Cheung, Esther W Chan, Angel Y S Wong, Lijia Chen, Ian C K Wong, Wai Keung Leung. “Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study. ” Gut, 2017; gutjnl-2017-314605 DOI: 10.1136/gutjnl-2017-314605